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Active Uptake of Oxalate in a Renal Tubular Cell Line (llc-pk1)

Year: 1993

Type: article

Abstract: The oxalate uptake was studied in LLC-PK1 cells, an epithelial cell line originated in proximal tubular cells of porcine kidney. It was clear that the cells contain an oxalate exchanger highly sensitive to 4,4-diisothio-cyanostilbene-2-' disulfonic acid (DIDS). The uptake was inhibited by the addition of inorganic anions (chloride, sulphate and bicarbonate) to the reaction system, but was unaffected by sodium ion. The data suggest the possibility that it should be consistent with at least two transport systems for oxalate in LLC-PK1 cells, a SO4-/oxalate/HCO3- exchanger and a Cl-/oxalate exchanger.

Source: The Japanese Journal of Urology

DOI: 10.5980/jpnjurol1989.84.1082

Authors: Shoichi Ebisuno, Tadashi Ohkawa, Cheryl Scheid, Mani Menon

Institutions: Minami Wakayama Medical Center, Wakayama Medical University, University of Massachusetts Chan Medical School

Language: Japanese

Topic: Kidney Stones and Urolithiasis Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2331420408

FWCI:

Cites: 13

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Related to: 10