Work

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

Year: 2016

Type: article

Abstract: The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of pharmaceuticals and natural products. For centuries, sulfur continues to maintain its status as the dominating heteroatom integrated into a set of 362 sulfur-containing FDA approved drugs (besides oxygen or nitrogen) through the present. Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades. In this review, these four moieties in pharmaceuticals and recent advances in the synthesis of the corresponding core scaffolds are presented.

Source: Current Topics in Medicinal Chemistry

DOI: 10.2174/1568026615666150915111741

Authors: Minghao Feng, Bingqing Tang, Steven H. Liang, Xuefeng Jiang

Institution: East China Normal University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Drug Abuse