Year: 2011
Type: article
Abstract: It is well known that primary hypertension is not isolated disorder but complex immunometabolic syndrome. Visceral obesity and disturbed relationship between subcutaneous and visceral fat depot, together with elevated blood pressure are regarded as the main cardiovascular risk factors. 40% of children and adolescents with newly diagnosed primary hypertension are at risk of target organ damage at the start of diagnosis what is enhanced by metabolic and immunological abnormalities related to visceral obesity. Compilation of standard pharmacological therapy based on ACE inhibitors with non-pharmacological treatment leads to normalization of blood pressure and metabolic profile in 70% of hypertensive children and is potentially beneficial in preventing long-term complications. But instead of blood pressure lowering, decrease of the ratio between visceral and subcutaneous fat depot is considered to be the main predictor of regression of target organ damage. (Forum Zaburzen Metabolicznych 2011, vol. 2, no 2, 124–131)
Source: Via Medica Journals
Authors: Mieczysław Litwin, Anna Niemirska
Language: Polish
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1762225179