The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation
Year: 2016
Type: article
Abstract: The microtubule-associated protein lissencephaly 1 (Lis1) is a key regulator of cell division during stem cell renewal and differentiation. In this study, we examined the role of Lis1 in T lymphocyte homeostasis and fate diversification in response to microbial infection. T cell-specific deletion of Lis1 resulted in depletion of the peripheral CD4(+) and CD8(+) T lymphocyte pool owing to a loss of homeostatic, cytokine-induced proliferation. In contrast, cognate Ag-triggered proliferation was much less affected, enabling Lis1-deficient CD8(+) T cells to differentiate into terminal effector cells in response to microbial infection. Strikingly, however, the specification of Lis1-deficient long-lived memory CD8(+) T lymphocytes was impaired due, in part, to an apparent failure to differentiate appropriately to IL-15. Taken together, these findings suggest that Lis1 plays an important role in T cell homeostasis and the generation of memory T lymphocytes.
Source: The Journal of Immunology
Authors: Soo M Ngoi, Justine M Lopez, John T Chang
Institution: University of California San Diego
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: The UCSD Digestive Diseases Research Development Center, Role of atypical Protein Kinase C in Inflammatory Bowel Disease, Understanding the Basis for Cellular Diversity During Adaptive Immunity, Regulation and Function of Polarity and Asymmetric Cell Division in Immunity, Training Grant in Gastroenterology, Asymmetric T cell division initiating adaptive immunity and colitis
OpenAlex ID: W2331855315