Studies on Extracellular Matrix Components That Promote Neurite Outgrowth
Year: 1983
Type: preprint
Abstract: An important determinant in the development of multicellular organisms is the extracellular matrix (ECM) upon which cells attach, migrate, and differentiate. It is likely that a class of substances that affect neuronal development will be found to be associated with the ECM. During early stages of neuronal development, strong spatial and temporal correlations are seen between the appearance of fibronectin and migration of granule cells to form the external granule cell layer in the cerebellum (Hatten et al. 1982) and migration of neural crest cells to form the variety of tissues derived from the crest (Thiery et al. 1982). When cerebellar granule cells or neural crest cells are cultured in vitro, their abilities to adhere to and migrate on fibronectin substrata correlate temporally with their migratory behaviors in vivo (Hatten et al. 1982; Rovasio et al. 1983).
Institution: University of California, San Francisco
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2331882413