Work

Genetic diagnosis of seronegative (HIV−) partner of female patient with AIDS in the context of HIV transmission

Year: 2016

Type: article

Abstract: Aim Complex genetic diagnosis of seronegative (HIV−) long-term partner of female patient with AIDS C3 in the context of HIV transmission. Case report and literature review. Background HIV infection was excluded in 47-year-old man, a long-term sexual partner of female patient diagnosed with AIDS C3. The risk of HIV infection was estimated as high. Objective We focused on the genetic diagnosis of serodiscordant couple. We determined the presence of CCR5-Δ32 , CCR2-64I , HLA-B , killer cell immunoglobulin-like receptor ( KIR ) and their ligand genes and human endogenous retroviruses K113 and K115. Methods Genotyping was performed using PCR methods. Results Analysis of partner's genotype revealed the presence of CCR5-Δ32/Δ32 and KIR genes encoding activating receptors ( KIR2DS1 , 2DS5 , 3DS1 ), features associated with reduced risk of HIV transmission. Similarities in patient's and her partner's HLA ( HLA-B*51 ) and similar inhibitory KIR repertoire and their ligands ( KIR2DL1+HLA-C2 , KIR2DL3+HLA-C1 , KIR3DL1+HLA-B Bw4-80Ile ) could favor the transmission of the virus. Conclusion Genetic diagnosis is not routinely recommended, observation of exposed and uninfected individuals would allow to implement new knowledge into more effective care.

Source: HIV & AIDS Review

DOI: 10.1016/j.hivar.2016.03.005

Authors: Katarzyna Zwolińska, Katarzyna Fleischer-Stępniewska, Brygida Knysz, Olga Błachowicz, Egbert Piasecki

Institutions: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw Medical University, Jan Długosz University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Ministerstwo Edukacji i Nauki