Work

The Addition of Extracorporeal Photophoresis (ECP) to Tacrolimus and Methotrexate to Prevent Acute and Chronic Graft-Versus Host Disease (aGvHD, cGvHD) in Patients Undergoing a Myeloablative (MA) Hematopoietic Cell Transplant (HCT)

Year: 2014

Type: article

Abstract: Acute and chronic GvHD occurs in 50-70% of patients undergoing HCT despite GvHD prophylaxis. In this study, ECP was added as GvHD prophylaxis for 10 treatments, 2 treatments prior to the start of the conditioning regimen and 8 after engraftment at two treatments every two weeks. All pts also received tacrolimus and methotrexate and 8 also received ATG. 20 pts (13 males, ages 28 – 57) were enrolled. All pts underwent a MA HCT (15 Bu-Cy and 5 Cy-TBI), 11 from matched unrelated, 5 from related and 4 from mismatched unrelated donors.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.12.357