Work

Synthesis of QS-21-Based Immunoadjuvants

Year: 2013

Type: article

Abstract: Three structurally defined QS-21-based immune adjuvant candidates (2a-2c) have been synthesized. Application of the two-stage activation glycosylation approach utilizing allyl glycoside building blocks improved the synthetic accessibility of the new adjuvants. The efficient synthesis and establishment of the stand-alone adjuvanticity of the examined synthetic adjuvant (2b) open the door to the pursuit of a new series of structurally defined QS-saponin-based synthetic adjuvants.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo402118j

Authors: Pengfei Wang, Qipu Dai, Punith Thogaripally, Ping Zhang, Suzanne M. Michalek

Institution: University of Alabama at Birmingham

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases