Year: 1994
Type: article
Study design: Clinical Trial
Abstract: Twenty post-stroke depressive patients who obtained more than 11 points on Self-Rating Questionnaire for Depression, were treated with 0.075 mg/day lisuride maleate for 12 weeks. The drug effect on depression was evaluated quantitatively by the Hamilton Rating Scale for Depression. The relationships between brain CT or MRI and SRQ-D score were investigated in 24 subjects. More than 80% of post-stroke depressive patients improved after lisuride maleate treatment for 8 or 12 weeks. In particular, depressed mood, hypobulia, sleep disturbance, anxiety, etc. were significantly improved compared to the baseline condition. As for the relationships with CT and/or MRI findings, the group with moderate to severe brain atrophy had a significantly higher grade of depressive state than those without.
Authors: Hidetaka Hougaku, Masayasu Matsumoto, Ryuji Hata, Nobuo Handa, Masatoshi Imaizumi, Yoshinori Sugitani, Shotaro Yoneda, Hideki Etani, Kenji Sueyoshi, Masahito Kusunoki, Osamu Uyama, Takenobu Kamada
Institution: The University of Osaka
Language: Japanese
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2332481096