S49 Telomere Attrition In Circulating White Blood Cells In Copd Relates To Lung Function And Outcomes
Year: 2014
Type: conference-abstract
Abstract: Introduction Increasing evidence suggests accelerated ageing as a pathogenic mechanism in COPD. Methods and results Telomere length in circulating WBC, a marker of biological ageing, was assessed in 200 ex-smoker COPD patients (108 male, age 61.5 ± 6.4 years, FEV1 45.6 ± 17.1% predicted), 50 ex-smokers with normal lung function (27 male, age 59.9 ± 7.3 years, FEV1 109.1 ± 13.4%predicted) and 50 non-smoker healthy subjects (27 male, age 59.3 ± 8.3 years, FEV1 113.2 ± 13.1% predicted). TL was assessed by qPCR and expressed as relative T/S ratio. TL was shorter in COPD (0.77 ± 0.2 relative T/S ratio) than in both ex-smokers (0.83 ± 0.2 relative T/S ratio) and non-smokers (0.84 ± 0.2 relative T/S ratio) (p < 0.05). Furthermore TL correlated negatively with age (r -0.17, p 0.007), emphysema score (r -0.217, p 0.001), number of exacerbations in the previous year to inclusion in the study (r -0.129, p 0.04), number of hospitalisations over 3 years follow-up (r -0.167, p 0.004) and positively with FEV1 (r 0.135, p = 0.03) and arterial oxygen saturation (r 0.161, p 0.01). Conclusion COPD patients have evidence of premature ageing (shortened TL) compared to normal subjects irrespective of their smoking history. TL relates to FEV1, SatO2, exacerbation rate and hospitalisations. The ECLIPSE study (GSK Study No. SCO104960, NCT00292552) was sponsored by GlaxoSmithKline.
Source: Thorax
Institutions: Centre for Inflammation Research, The Queen's Medical Research Institute, University of Glasgow, GlaxoSmithKline (United States), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Centro de Investigación Biomédica en Red, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2332490705