Year: 2008
Type: article
Abstract: In 1999, researchers extended X-ray crystallography to allow the imaging of non-crystalline specimens by measuring the X-ray diffraction pattern of a non-crystalline specimen and then directly phasing it using the oversampling method with an iterative algorithm.The new imaging modality, called coherent diffraction microscopy or lensless imaging, has since evolved moving in three important directions.The first is the three-dimensional (3D) structural determination of non-crystalline materials.The second is towards the 3D imaging of whole cells at a resolution of 10 nm or better.The third is the potential of imaging single large protein complexes using extremely intense and ultrashort X-ray pulses.In this talk, we will review the principle of coherent diffraction microscopy, and present some applications of the imaging modality to nanoscience and biology by using synchrotron radiation, high harmonic generation and soft X-ray laser sources.Finally, we will discuss the future opportunity with X-ray free electron lasers.
Institutions: University of Copenhagen, University of California, Los Angeles, European Synchrotron Radiation Facility, SPring-8, RIKEN, University of Kassel, National Institute of Standards and Technology, Joint Institute for Laboratory Astrophysics, University of Colorado Boulder, Institute of Physics, Academia Sinica, Academia Sinica, Lawrence Berkeley National Laboratory
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2333848850