Year: 2011
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Glioblastomas, the most common primary brain tumors in adults, still continue to have a predominantly fatal outcome.We previously cloned NPAS3 (neuronal PAS 3), a gene which is among the largest genes in the human genome and encodes a transcription factor.We recently discovered NPAS3 drives the progression of malignant astrocytomas as a tumor suppressor, by modulating the cell cycle, proliferation, apoptosis, and cell migration/invasion, and has a further influence on angiogenesis.In human glioblastoma surgical specimens, up to 75% demonstrate aberrant NPAS3 protein expression.In this study, we evaluated the expression of NPAS3 in the overall survival of patients diagnosed with glioblastomas.METHODS AND RESULTS: We examined a panel of glioblastomas from 77 postoperative patients who had total resection of the tumor.Postoperative patients were treated by standard adjuvant radiation therapy (60 Gy, 6 to 7 weeks) combined with chemotherapy, with a study follow-up not exceeding 30 months.Among the glioblastomas, 28 had absent, 18 had elevated, and 31 had normal NPAS3 expression.There were 54 males and 23 females in this study, with a median age of 59 years.In this study, patients with glioblastomas who had absent NPAS3 expression were identified as having the poorest overall survival compared with patients with glioblastomas who had normal or elevated NPAS3 expression (log-rank P value ,0.001).Such a trend is still maintained even when patients are stratified among different age groups (,60 and .60 years).However, no significant difference in overall survival among patients with glioblastomas who had either normal or elevated NPAS3 expression was noted (log-rank P value .0.05).Likewise, no significant difference in gender versus overall survival noted.CONCLUSION: Our findings are of clinical importance by demonstrating that NPAS3 is an informative negative prognostic survival marker in patients with glioblastomas. OM-02. PRELIMINARY USE OF DIFFERENTIAL SCANNING
Source: Neuro-Oncology
Authors: F. Moriera, K. So, P. Gould, D. Kamnasaran, R. L. Jensen, I. Hussain, D. H. Gutmann, D. Gorovets, E. R. Kastenhuber, E. Pentsova, L. Nayak, J. T. Huse, M. J. van den Bent, L. A. Gravendeel, T. Gorlia, J. M. Kros, P. Wesseling, J. Teepen, A. Idbaih, M. Sanson, P. A. S. Smitt, P. J. French, W. Zhang, J. Zhang, K. Hoadley, B. Carter, S. Li, C. Kang, Y. You, C. Jiang, S. Song, T. Jiang, C. Chen, C. Grimm, M. Weiler, R. Claus, D. Weichenhan, C. Hartmann, C. Plass, M. Weller, W. Wick, R. B. Jenkins, H. Sicotte, Y. Xiao, B. L. Fridley, P. A. Decker, M. L. Kosel, T. M. Kollmeyer, S. R. Fink, A. L. Rynearson, T. Rice, L. S. McCoy, I. Smirnov, T. Tehan, H. M. Hansen, J. S. Patoka, M. D. Prados, S. M. Chang, M. S. Berger, D. H. Lachance, J. K. Wiencke, J. L. Wiemels, M. R. Wrensch, M. H. Gephart, E. Lee, S. Kyriazopoulou-Panagiotopoulou, L. Milenkovic, X. Xun, Y. Hou, W. Kui, M. Edwards, S. Batzoglou, W. Jun, M. Scott, J. E. Hobbs, J. Tipton, T. Zhou, N. L. Kelleher, J. P. Chandler, J. Schwarzenberg, J. Czernin, T. Cloughesy, B. Ellingson, C. Geist, M. Phelps, W. Chen, M. Nakada, Y. Hayashi, W. Obuchi, S. Ohtsuki, T. Watanabe, C. Ikeda, K. Misaki, D. Kita, Y. Hayashi, N. Uchiyama, T. Terasaki, J.-i. Hamada, L. Hiddingh, B. Tops, E. Hulleman, G.-J. L. Kaspers, W. P. Vandertop, P. Wesseling, D. P. Noske, T. Wurdinger, J. W. Jeuken, A. P. See, T. Hwang, D. Shin, J. H. Shin, Y. Gao, M. Lim, M. Hutterer, M. Michael, U. Gerold, S. Karin, G. Ingrid, D. Florian, M. Armin, T. Eugen, G. Eberhard, S. Gunther, R. W. Cook, K. Oelschlager, H. Sevim, L. Chung, H. T. Wheeler, R. C. Baxter, K. L. McDonald, A. Chaturbedi, L. Yu, Y.-H. Zhou, A. Chaturbedi, A. Wong, R. Fatuyi, M. E. Linskey, Y.-H. Zhou, I. Lavon, T. Shahar, D. Zrihan, A. Granit, Z. Ram, T. Siegal, D. J. Brat, L. A. Cooper, D. A. Gutman, C. S. Chisolm, C. Appin, J. Kong, T. Kurc, E. G. Van Meir, J. H. Saltz, C. S. Moreno, H. J. Abuhusain, K. L. McDonald, A. S. Don, R. P. Nagarajan, B. E. Johnson, A. B. Olshen, I. Smirnov, M. Xie, J. Wang, V. Sundaram, P. Paris, T. Wang, J. F. Costello, A. E. Sijben, S. H. Boots-Sprenger, J. Boogaarts, J. Rijntjes, J. M. Geitenbeek, J. van der Palen, H. J. Bernsen, P. Wesseling, J. W. Jeuken, O. Schnell, S. A. Adam, S. Eigenbrod, H. A. Kretzschmar, J.-C. Tonn, U. Schuller, J. Schwarzenberg, T. Cloughesy, J. Czernin, C. Geist, M. Phelps, W. Chen, P. W. Sperduto, N. Kased, D. Roberge, Z. Xu, R. Shanley, X. Luo, P. K. Sneed, S. T. Chao, R. J. Weil, J. Suh, A. Bhatt, A. W. Jensen, P. D. Brown, H. A. Shih, J. Kirkpatrick, L. E. Gaspar, J. B. Fiveash, V. Chiang, J. P. Knisely, C. M. Sperduto, N. Lin, M. P. Mehta, M. M. Kwatra, T. M. Porter, K. E. Brown, J. E. Herndon, D. D. Bigner, R. H. Dahlrot, B. W. Kristensen, S. Hansen, E. P. Sulman, D. P. Cahill, M. Wang, M. Won, M. E. Hegi, M. P. Mehta, K. D. Aldape, M. R. Gilbert, E. S. Sadr, A. Tessier, M. S. Sadr, J. Alshami, C. Sabau, R. Del Maestro, M. L. Neal, R. Rockne, A. D. Trister, K. R. Swanson, S. Maleki, M. Back, M. Buckland, D. Brazier, K. McDonald, R. Cook, N. Parker, H. Wheeler, L. Jalbert, A. Elkhaled, J. J. Phillips, H. A. Yoshihara, R. Parvataneni, R. Srinivasan, G. Bourne, S. M. Chang, S. Cha, S. J. Nelson, K. D. Aldape, M. Gilbert, D. Cahill, M. Wang, M. Won, M. Hegi, H. Colman, M. Mehta, E. Sulman, A. Elkhaled, L. Jalbert, A. Constantin, J. Phillips, H. Yoshihara, R. Srinivasan, G. Bourne, S. M. Chang, S. Cha, S. Nelson, S. Gunn, X. T. Reveles, B. Tirtorahardjo, M. N. Strecker, L. Fichtel
Institutions: Radboud University Nijmegen, Université Laval, University of Utah, Huntsman Cancer Institute, European Organisation for Research and Treatment of Cancer, Hôpital de l'Enfant-Jésus, St. Elisabeth Hospital, Pitié-Salpêtrière Hospital, Erasmus MC, Rotterdam University of Applied Sciences, Erasmus University Rotterdam
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2334288558