Work

Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4

Year: 2014

Type: article

Abstract: A series of pyridine derivatives were synthesized as potential inhibitors of chemokine receptor type 4. This chemokine receptor has been linked to various disease pathways including HIV-1 proliferation, autoimmune disorders, inflammatory diseases, and cancer metastasis. The compounds were tested for activity using an affinity binding assay and an assay that tests the ability to inhibit cell invasion. Two hit compounds ( 2b and 2j ) have been identified for further evaluation that inhibit cell invasion by at least 50% and have an effective concentration of less than 100 n m in the binding affinity assay. The structures of the synthesized compounds were confirmed by spectral data.

Source: Heterocyclic Communications

DOI: 10.1515/hc-2014-0041

Authors: Suazette Reid Mooring, Theresa Gaines, Zhongxing Liang, Hyunsuk Shim

Institutions: Georgia State University, Emory University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,808