Work

Glutamatergic transmission in schizophrenia

Year: 2012

Type: article

Abstract: PURPOSE OF REVIEW: The past 20 years have seen the glutamatergic hypothesis go from theory to phase III trials of novel mechanism antipsychotics. RECENT FINDINGS: We review the recent literature on glutamatergic theory, covering assessment and genetic studies, as well as drug development in animals and humans. SUMMARY: Although evidence continues to accumulate in support of glutamate hypotheses, further research continues to be required and interactions with other key systems need to be explored.

Source: Current Opinion in Psychiatry

DOI: 10.1097/yco.0b013e32835035b2

Authors: Joshua Kantrowitz, Daniel C. Javitt

Institutions: Nathan Kline Institute for Psychiatric Research, Columbia University

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Mental Health, National Institute on Drug Abuse