Work

Inhibition of Nanoceria’s Catalytic Activity due to Ce 3+ Site-Specific Interaction with Phosphate Ions

Year: 2014

Type: article

Abstract: Cerium oxide nanoparticles (CNPs) exhibit superoxide dismutase (SOD) and catalase mimetic activities. Therefore, based on its catalytic activities, CNPs can potentially be used to treat diseases associated with oxidative stress. The potency of CNPs can be hindered by ion interaction due to chemical modifications. The issue is that phosphate ions are relatively ubiquitous in all biological relevance medium and body fluid. Our ventures in this study were to understand the phosphate ion interaction and fabricate CNPs that are biocompatible and simultaneously retain their catalytic properties in the presence of phosphate ions. CNPs were coated with polyethylene glycol and dextran in order to enhance biocompatibility. A series of experiments determined that maximizing the preserved catalytic responses were highly dependent on the Ce 3+:Ce 4+ . Results have shown that the particles engineered with higher concentrations of Ce 4+ on the surface are more robust and retain catalytic activity post buffer exposure.

Source: The Journal of Physical Chemistry C

DOI: 10.1021/jp500791j

Authors: Rameech N. McCormack, Priscilla Mendez, Swetha Barkam, Craig J. Neal, Soumen Das, Sudipta Seal

Institution: University of Central Florida

Language: English

Topic: Advanced Nanomaterials in Catalysis

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: University of Central Florida, Division of Chemical, Bioengineering, Environmental, and Transport Systems

Awards: G2399732614, G8320029856