Year: 2016
Type: article
Study design: Observational Study
Abstract: cancer research international: active surveillance (PRIAS), an American cohort (from Johns Hopkins), and a Canadian cohort (from Sunnybrook).These cohorts contained 5,129 follow-up biopsies in 3,412 PC patients.Calibration of the risk calculator was assessed graphically and the discriminative ability was quantified using the area under the receiver operating characteristic curve (AUC).Clinical usefulness was assessed using decision curves analysis (DCA).RESULTS: The AUC at external validation was 0.64 in PRIAS, 0.73 in the American cohort and 0.66 in the Canadian cohort.The probability of upgrading or risk reclassification was somewhat overestimated in PRIAS and the Canadian cohort and somewhat underestimated in the American cohort.DCA showed that the model was clinical useful in each cohort for risk thresholds between 10% and 30%.CONCLUSIONS: The risk calculator provided moderate discrimination in 3 cohorts of the GAP-3 consortium, but showed some miscalibration.Before applying the risk calculator in clinical practice recalibration may be required. Source of Funding: Submitted on behalf of the
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: Movember Foundation
OpenAlex ID: W2335287469