ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups
Year: 2016
Type: article
Study design: Study Protocol
Abstract: BACKGROUND: Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary aim is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups. METHODS: Studies focusing on individuals aged ≥95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress. DISCUSSION: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisation. A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments.
Source: BMC Neurology
Authors: Henry Brodaty, Claudia Woolf, Stacy Andersen, Nir Barzilai, Carol Brayne, Karen Siu-Lan Cheung, Maria M. Corrada, John D. Crawford, Catriona Daly, Yasuyuki Gondo, Bo Hagberg, Nobuyoshi Hirose, Henne Holstege, Claudia Kawas, Jeffrey Kaye, Nicole A. Kochan, Bobo Hi-Po Lau, Ugo Lucca, Gabriella Marcon, Peter Martin, Leonard W. Poon, Robyn Richmond, Jean-Marie Robine, Ingmar Skoog, Melissa J. Slavin, Jan Szewieczek, Mauro Tettamanti, José Viña, Thomas Perls, Perminder S. Sachdev
Institutions: UNSW Sydney, Dementia Collaborative Research Centres, Centre for Healthy Brain Ageing, St Vincent's Hospital Sydney, Boston University, Boston Medical Center, Albert Einstein College of Medicine, University of Cambridge, University of Hong Kong, University of California, Irvine, The University of Osaka, Lund University, Keio University, Amsterdam Neuroscience, Amsterdam UMC Location Vrije Universiteit Amsterdam, Oregon Health & Science University, Prince of Wales Hospital, Mario Negri Institute for Pharmacological Research, University of Udine, Iowa State University, University of Georgia, Inserm, Sahlgrenska University Hospital, Medical University of Silesia, Universitat de València
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,090
Funders: U.S. Department of Veterans Affairs, Alzheimer's Association, National Institute for Health and Care Research, University of New South Wales, Ministry of Health, Labour and Welfare, Vetenskapsrådet, Narodowym Centrum Nauki, Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Śląski Uniwersytet Medyczny w Katowicach, Stichting Dioraphte, Uniwersytet Śląski w Katowicach, National Institutes of Health, Medical Research Council, Japan Society for the Promotion of Science, National Institute on Aging
Awards: G1053040178, G2637832891, Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ Study, POPULATION BASED MULTIDISCIPLINARY STUDY OF CENTENARIANS, Oregon Alzheimer's Disease Center, Development of new successful aging model for super aging society, Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging, NIHR Senior Investigator Award, LGP/Longenity, G8670361978, G9000256225
OpenAlex ID: W2335826053