Work

Factor V: an active player in inflammation

Year: 2015

Type: article

Abstract: aPC with cofactor protein S (PS) and fV inhibits the EPCR-dependent activation of the inflammatory PAR2 signaling by destabilizing the ternary TF-VIIa-Xa complex.Without the R506 cleavage site, fV Leiden (FVL) loses its cofactor activity to facilitate aPC inhibition of the inflammatory signaling.

Source: Blood

DOI: 10.1182/blood-2015-09-669077

Author: Hongmin Sun

Institution: University of Missouri

Language: English

Topic: Blood Coagulation and Thrombosis Mechanisms

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2335979289