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A genome‐wide investigation of food addiction

Year: 2016
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Evidence of parallels between drug addiction and eating behavior continues to accumulate. Genetic studies of addictive substances have yielded a number of susceptibility loci that point to common higher order genetic pathways underlying addiction. It was hypothesized that a genome-wide association study (GWAS) of food addiction would yield significant enrichment in genes and pathways linked to addiction. METHODS: A GWAS of food addiction, determined by the modified Yale Food Addiction Scale (mYFAS), was conducted among 9,314 women of European ancestry, and results for enrichment of single-nucleotide polymorphisms (SNPs) (n = 44), genes (n = 238), and pathways (n = 11) implicated in drug addiction were examined. RESULTS: Two loci met GW-significance (P < 2.5 × 10(-8) ) mapping to 17q21.31 and 11q13.4 that harbor genes with no obvious roles in eating behavior. GW results were significantly enriched for gene members of the MAPK signaling pathway (P = 0.02). No candidate SNP or gene for drug addiction was significantly associated with food addiction after correction for multiple testing. CONCLUSIONS: In the first GWAS of mYFAS, suggestive loci worthy of further follow-up were identified, but limited support was provided for shared genetic underpinnings of food addiction and drug addiction. The latter might be due to limited study power and knowledge of the genetics of drug addiction.
Source: Obesity
DOI: 10.1002/oby.21476
Authors: Marilyn C. Cornelis, Alan Flint, Alison E. Field, Peter Kraft, Jiali Han, Eric B. Rimm, Rob M. van Dam
Institutions: Northwestern University, Harvard University, Indiana University Indianapolis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Brigham and Women's Hospital, National University of Singapore, National University Health System
Language: English
Field: Psychology
Open Access status: green
Funders: National Institutes of Health, National Human Genome Research Institute, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: A PROSPECTIVE STUDY OF DIET AND CANCER IN WOMEN, G1717613936, Indiana Clinical and Translational Sciences Institute, Biochemical Markers in the nurses' Health Study Cohort, Genes and Environment Initiatives in Type 2 Diabetes, Genome-Wide Association Study of Nonsynonymous SNPs in Colon Cancer, Genes and Environment Initiative in Glaucoma, G459566519, Life Course Cancer Epidemiology Cohort in Women, The Pathobiology of Nephrolithiasis, Molecular pathological epidemiology of colorectal cancer, Genetic Determinants of Taste Preferences and Risk of Metabolic Disease, Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, Premenopausal Hormone Levels and Risk of Breast Cancer
OpenAlex ID: W2336051871
FWCI: 6.635
Cites: 41
Cited by: 45
Related to: 10