Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Year: 2012
Type: article
Abstract: To identify novel loci for age at natural menopause, we performed a meta-analysis of 22 genome-wide association studies in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 new age at natural menopause loci (P < 5 × 10−8). The new loci included genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG, PRIM1) and immune function (IL11, NLRP11, BAT2). Gene-set enrichment pathway analyses using the full GWAS dataset identified exodeoxyribonuclease, NFκB signalling and mitochondrial dysfunction as biological processes related to timing of menopause.
DOI: 10.17615/zbd7-6y55
Authors: Lisette Stolk, John R. B. Perry, Daniel I. Chasman, Chanyi He, Massimo Mangino, Patrick Sulem, Maja Barbalić, Linda Broer, Enda M. Byrne, Florian Ernst, Tõnu Esko, Nora Franceschini, Daníel F. Guðbjartsson, J-J Hottenga, Peter Kraft, Patrick F. McArdle, E. Porcu, Sohyeon Shin, Albert V. Smith, S. van Wingerden, Guijin Zhai, Wei Vivian Zhuang, Eva Albrecht, Behrooz Z. Alizadeh, Thor Aspelund, Stefania Bandinelli, Lovorka Barać Lauc, J. Beckmann, Mladen Boban, Eric Boerwinkle, Frank J. Broekmans, Andrea Burri, Harry Campbell, Stephen J. Chanock, C. Chen, Marilyn C. Cornelis, Tanguy Corre, Andrea D. Coviello, Pio D’Adamo, Gareth E. Davies, Ulf dé Fairé, Eco J. C. de Geus, Ian J. Deary, George Dedoussis, Panos Deloukas, Shah Ebrahim, G. Eiríksdóttir, Valur Emilsson, Johan G. Eriksson, Bart C.J.M. Fauser, Liana Ferreli, Luigi Ferrucci, Krista Fischer, Aaron R. Folsom, M. E. Garcia, Paolo Gasparini, Christian Gieger, Nicole L. Glazer, D. E. Grobbee, Per Hall, Toomas Haller, S. E. Hankinson, Merli Hass, Caroline Hayward, Andrew C. Heath, Albert Hofman, Erik Ingelsson, A. Cecile J.W. Janssens, Austin Johnson, David Karasik, Sharon L. R. Kardia, Jules J. Keyzer, Douglas P. Kiel, Ivana Kolčić, Zoltán Kutalik, Jari Lahti, Sandra Lai, Triin Laisk, Joop S.E. Laven, Debbie A. Lawlor, J. Liu, Lorna M. Lopez, Yvonne V. Louwers, Páll Magnússon, Mara Marongiu, Nicholas G. Martin, Irena Martinović Klarić, Corrado Masciullo, Barbara McKnight, Sarah E. Medland, David Melzer, Vincent Mooser, Pau Navarro, Anne B. Newman, Dale R. Nyholt, N. Charlotte Onland‐Moret, Aarno Palotie, Guillaume Paré, Alexander N. Parker, Nancy L. Pedersen, P. H. M. Peeters, Giorgio Pistis, Andrew Plump, Ozren Polašek, Victor J.M. Pop, Bruce M. Psaty, Katri Räikkönen, Emil Rehnberg, Jerome I. Rotter, Igor Rudan, Cinzia Sala, Andres Salumets, Angelo Scuteri, Andy Singleton, Jennifer A. Smith, Harold Snieder, Nicole Soranzo, Simon Stacey, J.M. Starr, Maria G. Stathopoulou, Kathleen Stirrups, Ronald P. Stolk, Unnur Styrkársdóttir, Yan V. Sun, Albert Tenesa, Barbara Thorand, Daniela Toniolo, Laufey Tryggvadóttír, Kim Tsui, Sheila Ulivi, Rob M. van Dam, Yvonne T. van der Schouw, Carla H. van Gils, Pim van Nierop, Jacqueline M. Vink, Peter M. Visscher, Marlies Voorhuis, Gérard Waeber, Henri Wallaschofski, H-Erich Wichmann, Elisabeth Widén, C.J. Wijnands-van Gent, Gonneke Willemsen, J. Frank Wilson, B. H. Wolffenbuttel, Alan F. Wright, L.M. Yerges-Armstrong, Tatijana Zemunik, Lina Zgaga, M. Carola Zillikens, Marek Zygmunt, The LifeLines Cohort Study, Alice M. Arnold, Dorret I. Boomsma, Julie E. Buring, Laura Crisponi, Ellen W. Demerath, Vilmundur Guðnason, Tamara B. Harris, Fang Hu, David J. Hunter, Lenore J. Launer, Andres Metspalu, Grant W. Montgomery, B. A. Oostra, Paul M. Ridker, Serena Sanna, David Schlessinger, T. D. Spector, K. Stefansson, Elizabeth A. Streeten, U. Thorsteinsdottir, Manuela Uda, André G. Uitterlinden, Cornelia M. van Duijn, Henry Völzke, Alison D. Murray, Joanne M. Murabito, Jenny A. Visser, Kathryn L. Lunetta
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funder: McKnight Foundation
OpenAlex ID: W2336420417