Work

Cell cholesterol efflux: integration of old and new observations provides new insights

Year: 1999

Type: article

Abstract: Numerous studies using a variety of cell/acceptor combinations have demonstrated differences in cholesterol efflux among cells. These studies also show that different acceptors, ranging from simple molecules like cyclodextrins to serum, stimulate efflux through a variety of mechanisms. By combining early observations with data derived from recent studies, it is now possible to formulate a model for cell cholesterol efflux which proposes that an array of different mechanisms, including aqueous diffusion, lipid-free apolipoprotein membrane microsolubilization, and SR-BI-mediated cholesterol exchange contribute to cholesterol flux. In this model the relative importance of each mechanism would be determined both by the cell type and the nature of the extracellular cholesterol acceptor. —Rothblat, G. H., M. de la Llera-Moya, V. Atger, G. Kellner-Weibel, D. L. Williams, and M. C. Phillips. Cell cholesterol efflux: integration of old and new observations provides new insights. J. Lipid Res. 1999. 40: 781–796.

Source: Journal of Lipid Research

DOI: 10.1016/s0022-2275(20)32113-1

Authors: George H. Rothblat, Margarita de la Llera-Moya, Veronique Atger, Ginny Kellner-Weibel, David L. Williams, Michael C. Phillips

Institutions: Hôpital Broussais, State University of New York, Stony Brook University

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funder: National Heart, Lung, and Blood Institute