Work

Cardiac Localization of Eosinophil-Granule Major Basic Protein in Acute Necrotizing Myocarditis

Year: 1990

Type: article

Abstract: THE association of eosinophilia and endomyocarditis has been well documented. A form of Loffler's endocarditis,1 characterized by eosinophilic pancarditis, muscle necrosis, and arteritis, is usually a feature of certain systemic diseases, including the hypereosinophilic syndrome,2 3 4 eosinophilic leukemia,5 polyarteritis nodosa,6 , 7 drug-induced hypersensitivity,8 bronchial asthma,9 10 11 biliary tract carcinoma,12 and parasitic disease.13 The cardiac involvement is characterized by a subacute course and symptoms of congestive heart failure. Treatment with glucocorticoids and cytotoxic agents is effective.14 Fulminant acute necrotizing eosinophilic myocarditis occurring in the absence of notable extracardiac disease has been reported only rarely.15 The disease has a short course and is rapidly fatal. . . .

Source: New England Journal of Medicine

DOI: 10.1056/nejm199011293232207

Authors: Daphne E. deMello, Helen Liapis, Saadeh Jureidini, Soraya Nouri, Gail M. Kephart, Gerald J. Gleich

Institutions: Saint Louis University, Cardinal Glennon Children’s Medical Center, Mayo Clinic

Language: English

Topic: Eosinophilic Disorders and Syndromes

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases