Work

The Widening Sphere of Influence of HOXB7 in Solid Tumors

Year: 2016

Type: article

Abstract: Strong lines of evidence have established a critical role for the homeodomain protein HOXB7 in cancer. Specifically, molecular and cellular studies have demonstrated that HOXB7 is a master regulatory gene, capable of orchestrating a variety of target molecules, resulting in the activation of several oncogenic pathways. HOXB7 overexpression correlates with clinical progression and poor outcome of cancer patients. Specific inhibition of HOXB7 is particularly relevant in cancers still lacking effective therapies, such as tamoxifen-resistant breast cancer and melanoma. Mechanistic studies are providing additional targets of therapy, and biomarker studies are further establishing its importance in early diagnosis and prognosis. Cancer Res; 76(10); 2857-62. ©2016 AACR.

Source: Cancer Research

DOI: 10.1158/0008-5472.can-15-3444

Authors: Maria Cristina Errico, Kideok Jin, Saraswati Sukumar, Alessandra Carè

Institutions: Istituto Superiore di Sanità, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministry of Health, Ministero della Salute, Associazione Italiana per la Ricerca sul Cancro, National Cancer Institute