Paediatric European Risperidone Studies (PERS): context, rationale, objectives, strategy, and challenges
Year: 2013
Type: article
Abstract: In children and adolescents with conduct disorder (CD), pharmacotherapy is considered when non-pharmacological interventions do not improve symptoms and functional impairment. Risperidone, a second-generation antipsychotic is increasingly prescribed off-label in this indication, but its efficacy and tolerability is poorly studied in CD, especially in young people with normal intelligence. The Paediatric European Risperidone Studies (PERS) include a series of trials to assess short-term efficacy, tolerability and maintenance effects of risperidone in children and adolescents with CD and normal intelligence as well as long-term tolerability in a 2-year pharmacovigilance. In addition to its core studies, secondary PERS analyses will examine moderators of drug effects. As PERS is a large-scale academic project involving a collaborative network of expert centres from different countries, it is expected that results will lead to strengthen the evidence base for the use of risperidone in CD and improve standards of care. Challenging issues faced by the PERS consortium are described to facilitate future developments in paediatric neuropsychopharmacology.
Authors: Jeffrey Glennon, Diane Purper-Ouakil, Mireille Bakker, Alessandro Zuddas, Pieter Hoekstra, Ulrike Schulze, Josefina Castro-Fornieles, Paramala J. Santosh, Celso Arango, Michael Kölch, David Coghill, Itziar Flamarique, Maria J. Penzol, Mandy Wan, Macey Murray, Ian C. K. Wong, Marina Danckaerts, Olivier Bonnot, Bruno Falissard, Gabriele Masi, Jörg M. Fegert, Stefano Vicari, Sara Carucci, Ralf W. Dittmann, Jan K. Buitelaar
Institutions: Radboud University Nijmegen, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Inserm, Hôpital Saint Eloi, Centre for Psychiatry and Neuroscience, University of Cagliari, University Medical Center Groningen, University of Groningen, Universität Ulm, Centro de Investigación Biomédica en Red de Salud Mental, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, King's College London, South London and Maudsley NHS Foundation Trust, Hospital General Universitario Gregorio Marañón, University of Dundee, Ninewells Hospital, UCL School of Pharmacy, University College London, University of Hong Kong, KU Leuven, Fondazione Stella Maris, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, Central Institute of Mental Health
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $2,990
OpenAlex ID: W2113278311