Work

Sex-specific patterns and differences in dementia and Alzheimer’s disease using informatics approaches

Year: 2016

Type: article

Abstract: The National Institutes of Health Office of Research on Women's Health recently highlighted the critical need for explicitly addressing sex differences in biomedical research, including Alzheimer's disease and dementia. The purpose of our study was to perform a sex-stratified analysis of cognitive impairment using diverse medical, clinical, and genetic factors of unprecedented scale and scope by applying informatics approaches to three large Alzheimer's databases. Analyses suggested females were 1.5 times more likely than males to have a documented diagnosis of probable Alzheimer's disease, and several other factors fell along sex-specific lines and were possibly associated with severity of cognitive impairment.

Source: Journal of Women & Aging

DOI: 10.1080/08952841.2015.1018038

Authors: Jay Geronimo Ronquillo, Merritt Rachel Baer, William T. Lester

Institutions: Library of Virginia, Harvard University, Massachusetts General Hospital

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities, Gender equality

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering