Optimization of cancer chemotherapy: local delivery of paclitaxel and pharmacokinetics of suramin
Year: 2004
Type: article
Abstract: Cancer remains a major public health problem in the United States and in other developed countries.One in four deaths in the United States is caused by cancer.Although our knowledge in tumor biology has exploded during the last decades, it has not been accordingly translated into new substantially better anticancer drugs.It has been reported that only 12 among a total of 209 investigational approaches or drugs showed statistically significant benefit from January 1996 to October 2002.Besides the heterogeneity of tumors and the redundant signaling pathways for the tumor to evade the drug's toxic effect, drug delivery and dosing regimen compose two major limitations for anticancer drug efficacy.This dissertation is focused on these two aspects to optimize cancer chemosensitization.An ideal formulation for chemotherapy would be able to deliver high concentration of drug to the tumor while sparing other organs.This formulation would especially be preferred in the treatment of prostate cancer.Prostate cancer is the most common malignancy in man, with estimated 230,110 new cancer cases and 29,900 deaths in 2004.Over the past decade, the development of diagnosis techniques has resulted in a stage migration.A retrospective study shows from 1992 to 1998, 82% of newly diagnosed cases were localized.Current treatment options for localized prostate cancer are accompanied by side effects such as impotence and incontinence.These side effects can compromise a patient's quality of life.The work presented in this x
Author: Xiao Hu
Institution: The Ohio State University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2338756018