Work

Emerging Roles of Protein Deamidation in Innate Immune Signaling

Year: 2016

Type: review

Abstract: Protein deamidation has been considered a nonenzymatic process associated with protein functional decay or "aging." Recent studies implicate protein deamidation in regulating signal transduction in fundamental biological processes, such as innate immune responses. Work investigating gammaherpesviruses and bacterial pathogens indicates that microbial pathogens deploy deamidases or enzyme-deficient homologues (pseudoenzymes) to induce deamidation of key signaling components and evade host immune responses. Here, we review studies on protein deamidation in innate immune signaling and present several imminent questions concerning the roles of protein deamidation in infection and immunity.

Source: Journal of Virology

DOI: 10.1128/jvi.01980-15

Authors: Jun Zhao, Junhua Li, Simin Xu, Pinghui Feng

Institution: USC Norris Comprehensive Cancer Center

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Dental and Craniofacial Research