Work

Pathological Changes of the Blood Cells in Fluconazole Treated Toads

Year: 2005

Type: article

Abstract: Fluconazole is a triazole antifungal agent used for the treatment of certain superficial and systemic infections which predominantly affect immunocompromised individuals.Force-feeding toads with fluconazole at therapeutic dose level (0.26 mg/toad) for 20 weeks resulted in pronounced alterations of the blood cells of the peripheral blood.Most leucocytes showed irregularities in nuclear configuration, cytoplasmic vacuolation, pleomorphic granules and a paucity of organelles.These alterations are more or less similar to those reported in humans with leukaemia and were comparable to those observed after the administration of the carcinogenic chemical 7,12 dimethylbenz(a) anthracene (DMBA).

Source: ScienceAsia

DOI: 10.2306/scienceasia1513-1874.2005.31.043

Authors: Amina E Essawy, Abdelmoneim H El-Zoheiry, Mohamed M El-Mofty, Suzan F Helal, Ehab M El-Bardan

Institution: Alexandria University

Language: English

Topic: Immunotoxicology and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4252867605