Work

Estimating IBD tracts from low coverage NGS data

Year: 2016

Type: article

Abstract: MOTIVATION: The amount of IBD in an individual depends on the relatedness of the individual's parents. However, it can also provide information regarding mating system, past history and effective size of the population from which the individual has been sampled. RESULTS: Here, we present a new method for estimating inbreeding IBD tracts from low coverage NGS data. Contrary to other methods that use genotype data, the one presented here uses genotype likelihoods to take the uncertainty of the data into account. We benchmark it under a wide range of biologically relevant conditions and show that the new method provides a marked increase in accuracy even at low coverage. AVAILABILITY AND IMPLEMENTATION: The methods presented in this work were implemented in C/C ++ and are freely available for non-commercial use from https://github.com/fgvieira/ngsF-HMM CONTACT: [email protected] SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Source: Bioinformatics

DOI: 10.1093/bioinformatics/btw212

Authors: Filipe G. Vieira, Anders Albrechtsen, Rasmus Nielsen

Institutions: Natural History Museum of Denmark, University of Copenhagen, University of California, Berkeley

Language: English

Topic: Genetic diversity and population structure

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Lundbeckfonden

Award: G1518860217