Work

New aspects of immune responses against mycobacteria: immunopharmacology studies

Year: 1998

Type: article

Abstract: Host’s resistance against tuberculosis relies on classical \nMHC-dependent immunity and on CD1-restricted \nresponses against non-peptide antigens (e.g. \nmycolic acid) presented by cytokine-activated monocytes \n(CAM) to CD3+, CD4–/CD8– (i.e.,double-negative, \nDN) T cells. A number of antitubercular or anti-HIV \nagents do not impair the in vitro induction of CD1b \nmolecule by GM-CSF on normal monocytes, or the \nfunctional activity of DNT cells. However, azydothymidine \nreduces CAM number, whereas Rifampin \nincreases CD1b expression. These results point out \nthat immunopharmacological analysis of chemotherapeutic \nagents should include the CD1-dependent \nimmune system.

Source: Cineca Institutional Research Information System (Tor Vergata University)

Authors: Enzo Bonmassar, Arthur Aquino, Alessandro Giuliani, Steven A. Porcelli, Lucio Tentori, Salvatore Pasquale Prete, Malcolm K. Brenner, I. Cirello, Daniela Cappelletti, G. Graziani

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2339624413

FWCI:

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