Work

Non-substrate based, small molecule inhibitors of the human isoprenylcysteine carboxyl methyltransferase

Year: 2016

Type: article

Abstract: Screening and subsequent medicinal chemistry gave a new chemotype for hICMT inhibitors.

Source: MedChemComm

DOI: 10.1039/c6md00130k

Authors: Kyle V. Butler, Kelsey Bohn, Christine A. Hrycyna, Jian Jin

Institutions: Icahn School of Medicine at Mount Sinai, Purdue University West Lafayette

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, National Institutes of Health, National Institute of Mental Health, National Institute of General Medical Sciences

Awards: G1666267328, G3724751891, G393912048, G4952263264, G5858278710, G9000018244, G9000079072, G9000083847, G9000086174

OpenAlex ID: W2339901335

FWCI: 0.301

Cites: 38

Cited by: 6

Related to: 10