Zmienność dobowa dyspersji QT u pacjentów z chorobą wieńcową
Year: 2005
Type: article
Study design: Observational Study
Abstract: Background: The frequency of onset of acute coronary syndromes and sudden cardiac death has been reported to have a cicardian variations, with a peak incidence in early morning hours. It has also been known that acute ischemia is a potent stimulus to increased dispersion of repolarization and development of malignant arrhythmias. QT dispersion (QTd) is used as an index of heterogenity of the ventricular repolarization and increases in patients with ischemic heart disease. The aim of the study was to investigate diurnal variations of QTd. Material and methods: We investigated 48 patients with stable coronary artery disease (CAD) who had been referred for coronary angiography, of whom 29 had one-vessel disease, 10 had double-vessel disease and 9 had triple-vessel disease. We excluded patients with prior myocardial infarction, taking oral medications which might alter QT interval and patients with diabetes mellitus. QTd measurements were taken semiautomatically every hour from 24 hours 12 leads Holter monitoring system (SUPRIMA 12). Measurements were verified independently by three observers. Results: QTd was significantly greater in the morning hours (6.00–9.00) in comparision with the other times (p < 0.01). The shortest QTd was measured during the night between 10 p.m. and 1 a.m. Conclusions: Our data proved that QTd in patients with CAD has a circadian variation with a peak value in the morning hours shortly after awakening. (Folia Cardiol. 2005; 12: 667–672) QT dispersion, circadian variation, coronary artery disease, Holter monitoring
Language: Polish
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2340068501