Work

Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity

Year: 2016

Type: review

Abstract: Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies will be realized through parallel profiling of genomic, transcriptional, and epigenetic information.

Source: Genome biology

DOI: 10.1186/s13059-016-0944-x

Authors: Stephen J. Clark, Heather J. Lee, Sébastien A. Smallwood, Gavin Kelsey, Wolf Reik

Institutions: Babraham Institute, Wellcome Sanger Institute, Friedrich Miescher Institute, University of Cambridge

Language: English

Topic: Single-cell and spatial transcriptomics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,490

Funders: Wellcome Trust, Medical Research Council, Biotechnology and Biological Sciences Research Council, Seventh Framework Programme