Year: 2014
Type: article
Abstract: Statins are widely used to lower lipid levels and prevent cardiovascular disease. Recently described anti-inflammatory and immunomodulating properties of statins substantiate their application as a potentially novel treatment for autoimmune diseases. We evaluated efficacy and safety of simvastatin (40 mg daily) in patients with active rheumatoid arthritis (RA), as a supplement to stable doses of disease-modifying antirheumatic drugs. After 12 weeks of treatment, there was registered a significant decrease in disease activity score (by 0.89 points), improvement of life quality, and attenuation of pain levels. To confirm efficacy and safety of simvastatin in active RA, a large-scale controlled randomized study should be performed.
Source: Medical Immunology (Russia)
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2172888017