Work

The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats.

Year: 2016

Type: article

Abstract: OBJECTIVES: Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN 55,212-2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. MATERIALS AND METHODS: Diabetes was induced in rats using a single dose of streptozotocin (45 mg/kg IP). RESULTS: Intrathecal (IT) administration of WIN55, 212-2 (1, 10, 100 µg/10 µl, IT), produced antinociceptive effects in the hot plate test and also improved nerve conduction velocity (100 µg/10 µl, IT) and sciatic nerve histology. CONCLUSION: These data show that cannabinoids have potent antinociceptive effects through direct actions in the spinal dorsal horn of nociceptive pathway. This suggests that intrathecally administered cannabinoids may offer hopeful strategies for the treatment of diabetic neuropathic pain.

Source: PubMed Central

Authors: Samane Jahanabadi, Mohamad Reza Hadian, Javad Shamsaee, Seyed Mohammad Tavangar, Alireza Abdollahi, Ahmadreza Dehpour, Shahram Ejtemaei Mehr

Institutions: Shahid Sadoughi University of Medical Sciences and Health Services, Tehran University of Medical Sciences

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Tehran, Tehran University of Medical Sciences and Health Services

OpenAlex ID: W2340337808

FWCI: 1.199

Cites: 54

Cited by: 9

Related to: 10