Year: 1980
Type: dissertation
Abstract: More generally, the purpose of this thesis is to attempt a better understanding of the consequences of short term selection programmes on genetic variability.The first eight chapters of this thesis deal with directional selection.Some theory is developed for the case of two locus models in order to understand the way the various parameters interact during the selection process.Attempts are made to extend the two locus results to quantitative models and considerable use is here made of Montecarlo simulation studies.At the end of this part of the thesis, experiments withDrosophilamelanogaster are reported.These experiments were carried out to provide experimental evidence on the theory developed in earlier chapters.The last chapters of the thesis deal with disruptive selection.Under this type of selection, gene frequency changes are small and most of the change in genetic parameters comes about through the generation of linkage disequilibrium.An experiment with Drosophila is described, the results of which are interpreted in the light of theoretical work based on some simple algebra and computer simulation, CHAPTER 2 POPULATION GENETICS OF TWO LOCUS MODELS From (2.7) and (2.10) we conclude that the amount of linkage disequilibrium generated in the gametes produced by the selected genotypes after the first cycle of selection.is not dependent on c and is equal to the disequilibrium present within the chromosomes of the selected genotypes.That is, D = D (1) provided D ° = 0. 10.Several of these points will be pursued further in later sections.
Source: ERA
Author: Daniel Sørensen
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2340552954