Work

Regulation of synthesis of ribosomal proteins during pyrimidine starvation in Escherichia coli

Year: 1975

Type: article

Abstract: The synthesis of ribosomal proteins during pyrimidine starvation was investigated. A progressive turn-off of protein synthesis, with a decay half-time of about 5 min, was observed when Escherichia coli cells were starved of uridine. By means of double-labelling, the syntheses of different ribosomal proteins were shown to be turned off unequally during the starvation. Comparison of the turn-off patterns for some proteins and the known polycistronic organization of the structural genes for these proteins suggests that a major cause of the unequal turn-off was the degradation of mRNA molecules for the ribosomal proteins from the 5'-end toward the 3'-end.

Source: Biochemical Journal

DOI: 10.1042/bj1500463

Authors: B G Beatty, W W Mak, J T Wong

Institution: University of Toronto

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Medical Research Council Canada, Medical Research Council

OpenAlex ID: W2340614952