Development of Self-assembled Amphiphilic Oligo-urethanes as Cardiovascular Drug Delivery Platforms
Year: 2015
Type: dissertation
Abstract: Current drug-coated balloon (DCB) technologies, used to prevent percutaneous coronary intervention-related restenosis via antiproliferative agent delivery to arterial lesions, are associated with systemic drug loss during catheter tracking and inefficient drug delivery to target tissues. This thesis aimed to study and synthesize novel amphilphilic oligo-urethanes (AOUs) as DCB drug carriers comprised of polyol, lysine diisocyanate and perfluoro-alcohol (PFA) segments to enhance drug release, binding and shielding against premature release respectively. AOU syntheses employing di-hydroxyl polyols were found to be susceptible to pre-polymer intramolecular cyclization, which prevented PFA conjugation. Such undesired cyclization reactions were circumvented in this thesis via the use of a mono-functional polyol to yield AOU analogues that were water soluble (≥430 mg/mL solubility) and relatively phase mixed. Fluorocarbon groups migrated to the surfaces of analogue films, yielding water contact angle values ≤51o. Preliminary analogue-cell compatibility studies and capillary electrophoresis-mediated drug-AOU dissociation assessments were conducted and are reported.
Source: TSpace (University of Toronto)
Author: Maneesha A. Rajora
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2340773655