MR anatomy of the substantia innominata and findings in Alzheimer disease: a preliminary report.
Year: 1995
Type: article
Study design: Observational Study
Abstract: PURPOSE: To demonstrate normal MR anatomy of the substantia innominata and its changes in Alzheimer disease on MR imaging. METHODS: Using a 1.5-T superconductive MR unit, thickness of the substantia innominata was measured on coronal thin-section images obtained in 22 patients with Alzheimer disease and 14 age-matched control subjects. Comparison of these images with postmortem specimens of human brain was also performed. RESULTS: On T2-weighted images through the anterior commissure, the substantia innominata was clearly identified between the globus pallidus and the anterior perforated substance. In Alzheimer disease, thinning of the substantia innominata was more frequently observed than in the age-matched controls. CONCLUSION: Thin-section T2-weighted coronal MR images can demonstrate shrinkage of the substantia innominata, a finding that may aid in the diagnosis of Alzheimer disease.
Source: PubMed
Authors: M Sasaki, S Ehara, Y Tamakawa, S Takahashi, H Tohgi, A Sakai, T Mita
Institution: Iwate Medical University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2341037473