Year: 2009
Type: article
Abstract: Studies have shown the benefits of low-carbohydrate diets on reducing weight in obese subjects.Establishing a mouse model to further evaluate the safety and efficacy of these diets is warranted due to controversial issues about the safety and efficacy of lowcarbohydrate diets.In the present study, 40 diet-induced obese mice were split into 5 groups and placed on 1 of 5 diets: a HF diet (HF-HF), a standard chow (SC), three 2% carbohydrate diets with 5% protein (HF-LC5), 10% protein (HF-LC10), and 15% protein (HF-LC5), respectively.10 mice were fed standard chow (SC-SC) as a non-obese control for whole study.The results showed that the body weights of mice in the HF-LC5, HF-LC10, HF-LC15 and HF-SC groups decreased with time.The most significant decrease in body weight was noted for the HF-LC5 (33%) and HF-SC (23%) mice.Accordingly, the percentage of fat mass decreased in the HF-LC5, HF-LC10, HF-LC15 and HF-SC groups with the most dramatic decrease in fat mass noted for the HF-LC5 and HF-SC groups.Similar energy consumption of low-carbohydrate diet groups to SC-SC group and small percentage of total weight loss in fluid mass suggested limited calorie intake and body water loss did not account for the majority of body weight loss with lowcarbohydrate diets.The low-carbohydrate diet groups had increased levels of HDL and urinary ketones, as well as decreased levels of plasma insulin, IGF-1 blood glucose,
Author: Yufeng Zhai
Institution: Ohio University
Language: English
Topic: Diet and metabolism studies
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2341132109