Year: 1936
Type: article
Abstract: THE interesting theory of Szent-Gy6rgyi and co-workers [Annau et al., 1935] that in respiration the system fumarate-oxaloacetate functions catalytically in transporting activated metabolite hydrogen to the cytochrome (Warburg-Keilin) system has received support in the experiments of Stare & Baumann [1936].Using the manometric method with pigeon breast muscle and heart muscle (swine), the latter investigators observed the following: "1.The oxygen uptake of tissues is increased by very small amounts of fumarate and the increase is much greater than can be accounted for by the oxidation of the fumarate itself.2. Small amounts of added fumarate are detectable after prolonged contact with respiring tissue.3. The increased respiration is normal, that is, the respiratory quotient is not materially changed by the addition of small amounts of fumarate.4. Substances which yield fumarate on contact with tissue-succinate, malate, oxaloacetate-show a similar action to fumarate itself."Recently Szent-Gy6rgyi and co-workers [Annau et at., 1936] have applied quantitative methods for the micro-estimation of oxaloacetic, pyruvic, and malic acids and have given additional evidence in support of their theory.They followed chemically the disappearance of oxaloacetic acid added to muscle and
Source: Biochemical Journal
DOI: 10.1042/bj0302257
Author: Fredrick John Stare
Institution: University of Szeged
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2341399491