Effects of flavonoids from Martynia annua and Tephrosia purpurea on cutaneous wound healing.
Year: 2016
Type: article
Abstract: OBJECTIVE: . MATERIALS AND METHODS: (TPF-A) were evaluated for healing potential in dead-space and burn wound models. An ointment (5% w/w) of MAF-C and TPF-A, pongamol (0.2 and 0.5% w/w) and luteolin (0.2 and 0.5% w/w) was applied topically twice a day. The effects were compared with Povidone Iodine ointment with respect to protein, collagen content, enzymatic assay and histopathological finding of granuloma tissues. RESULTS: . TPF-A and MAF-C ointments (5% w/w) significantly increases the hydroxyproline and protein contents. Luteolin and pongamol ointments were also found to be effective in both wound models. CONCLUSION: Our findings suggested that 5% w/w ointment of TPF-A and MAF-C fractions were more effective than isolated flavonoids in wound healing which may be due to synergistic interactions between the flavonoids and other constituents.
Source: PubMed Central
Authors: Santram Lodhi, Avijeet Jain, Alok Pal Jain, Rajesh Singh Pawar, Abhay Kumar Singhai
Institutions: Dr. Hari Singh Gour University, RKDF University
Language: English
Topic: Wound Healing and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2341426326