Role of B cells in the development of multiple sclerosis and experimental autoimmune encephalomyelitis
Year: 2013
Type: article
Abstract: Multiple sclerosis, also known as MS, is a chronic disease that attacks the central nervous system and is characterized by damaged myelin sheaths around the axons accompanied by broad spectrum of signs and symptoms. The cause of MS remains unknown. It is considered that MS occurs as a result of combination of genetic, autoimmune mechanisms and environmental factors. MS is regarded to be autoimmune disease due to development of host immune response against its own molecules in nervous system. Until recently, the prevalent opinion was that T cells have the greatest importance in the development of certain autoimmune diseases, including multiple sclerosis. In recent years, increased interest to examine the physiological and pathological roles of B cells, has made a new understanding of the importance of these cells. Thanks to new research, it has been shown that in addition to humoral immunity, B lymphocytes are of great importance in the development and regulation of cellular immunity and in linking innate and acquired immune responses. The importance of B cells in the development of multiple sclerosis and in animal model of the disease, experimental autoimmune encephalomyelitis (EAE), is now clearly demonstrated, but all of the mechanisms used by these cells that contribute to the pathogenesis of the disease are still not clear. Importance of B cells is confirmed by modern therapeutic options for the treatment of multiple sclerosis.
Source: PONS - medicinski casopis
DOI: 10.5937/pomc10-3867
Authors: Jovicic Nemanja, Jeftic Ilija, Jovicic Ugljesa
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2049735405