Year: 2016
Type: editorial
Abstract: Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress. We reported that direct binding of p53 at human subtelomeres corresponds with local transcription activation and enhanced telomere stability in the presence of DNA damage.
Source: Molecular & Cellular Oncology
Authors: Stephen Tutton, Paul M. Lieberman
Institution: The Wistar Institute
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Cancer Institute
Award: G69874486
OpenAlex ID: W2341835778