Work

Breaking bad habits: Targeting MDSCs to alleviate immunosuppression in prostate cancer

Year: 2015

Type: article

Abstract: The myeloid-derived suppressor cells (MDSCs) contribute to tumor immune evasion and still remain an elusive therapeutic target. Our study identified granulocytic MDSCs accumulating in prostate cancer patients during disease progression. We demonstrate the feasibility of using STAT3siRNA-based strategy for targeting MDSCs to alleviate arginase-dependent suppression of T cell activity.

Source: OncoImmunology

DOI: 10.1080/2162402x.2015.1078060

Authors: Sumanta K. Pal, Marcin Kortylewski

Institutions: City Of Hope National Medical Center, Beckman Research Institute

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913