Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
Year: 2016
Type: article
Abstract: Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.
Source: Scientific Reports
DOI: 10.1038/srep24828
Authors: Vilma Aho, Hanna M. Ollila, Erkki Kronholm, Isabel Bondia-Pons, Pasi Soininen, Antti J. Kangas, Mika Hilvo, Ilkka Seppälä, Johannes Kettunen, Mervi Oikonen, Emma Raitoharju, Tuulia Hyötyläinen, Mika Kähönen, Jorma S.A. Viikari, Mikko Härmä, Mikael Sallinen, Vesa M. Olkkonen, Harri Alenius, Matti Jauhiainen, Tiina Paunio, Terho Lehtimäki, Veikko Salomaa, Matej Orešič, Olli T. Raitakari, Mika Ala-Korpela, Tarja Porkka-Heiskanen
Institutions: University of Helsinki, Helsinki University Hospital, Finnish Institute for Health and Welfare, Institute for Molecular Medicine Finland, Stanford University, Steno Diabetes Centers, VTT Technical Research Centre of Finland, University of Eastern Finland, University of Oulu, Tampere University, Fimlab (Finland), University of Tampere, University of Turku, Tampere University Hospital, Turku University Hospital, Finnish Institute of Occupational Health, University of Jyväskylä, Minerva Foundation, Oulu University Hospital, University of Bristol, MRC Integrative Epidemiology Unit
Language: English
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: Foundation for Cardiovascular Research, Helsingin ja Uudenmaan Sairaanhoitopiiri, Yrjö Jahnssonin Säätiö, Finska Läkaresällskapet, British Heart Foundation, Kela, Academy of Finland, Suomen Kulttuurirahasto, Työsuojelurahasto, Tekes, Juho Vainion Säätiö, Magnus Ehrnroothin Säätiö, Novo Nordisk, Emil Aaltosen Säätiö, Sydäntutkimussäätiö, Oulun Yliopisto, Tampereen Tuberkuloosisäätiö, Orionin Tutkimussäätiö, Paavo Nurmen Säätiö, Novo Nordisk Fonden, Turun Yliopistollinen Keskussairaala, Diabetestutkimussäätiö, Medical Research Council, Jenny ja Antti Wihurin Rahasto, Instituto de Salud Carlos III
Awards: G1037428335, G144353923, G1858620458, G1891033315, G2026946236, G2109129306, G2174313116, G2230772921, G2513778610, G4139205196, G4303067336, G4321089066, G5090981026, G5147590644, G5474452856, G5489727732, G5495782647, G5769834892, G5770909501, G6164432047, G6355767702, G786184032, G831026002, G992154238
OpenAlex ID: W2342297585