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Étude de la relation complexe entre trouble dépressif unipolaire et trouble neurocognitif par une revue de la littérature

Year: 2016
Type: dissertation
Abstract: The existence of an association between depression and dementia has been pointed out, and the scientific literature on the subject is growing. Our literature review provides an overview of the updated study about the relationship between unipolar depression and neurocognitive disorders. It begins with a reminder of the fundamental notions of unipolar depressive disorder and its characteristics in the elderly and neurocognitive disorders. After reporting the clinical and epidemiological similarities between depression and dementia, it showed strong arguments, but not consensus, which suggests the existence of an association between these two entities. The risk of dementia appears to be twice as high in subjects with a history of depression, compared to those without. Several forms of association have been studied, and the notion of temporality between the occurrence of these diseases appears essential. Depressions with early beginning may consist of a risk factor for dementia Alzheimer or vascular dementia, while those with late onset would consist of a prodromal symptom of dementia. Other assumptions are appearing in the literature and are interesting although they remain to strengthen, the continuum between depression and dementia, involvement of benzodiazepines consumption, etc. On the pathophysiology side, the link between these two entities appears to result from an entanglement of several mechanisms (inflammatory, genetic, vascular, etc.). A better understanding of the link between these diseases could have major implications for patients and public health (screening, prevention, early care, etc.) and warrants further studies on the subject.
Source: HAL
Language: French
Field: Medicine
Open Access status: green
OpenAlex ID: W2342746835
Cites: 286
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Related to: 10