MENA Promotes Tumor-Intrinsic Metastasis through ECM Remodeling and Haptotaxis
Year: 2016
Type: article
Abstract: Oudin and colleagues report a novel and specific function of MENA in mediating directional migration of breast cancer cells toward a fibronectin gradient of increasing concentration. This MENA-mediated haptotactic response depends on the binding of MENA to the α5β1 integrin receptor, adhesion protein signaling, and fibronectin fibrillogenesis. Cancer Discov; 6(5); 474-6. ©2016 AACRSee related article by Oudin et al., p. 516.
Source: Cancer Discovery
Authors: Miguel Santiago-Medina, Jing Yang
Institutions: University of California San Diego, Moores Cancer Center
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Regulation of Tumor Invasion by Twist1, REGULATION OF BREAST CANCER STEM CELL BY TISSUE RIGIDITY, G537854483, Neuroscience Training Program, Specialized Cancer Center Support Grant, Dissecting molecular determinants of carcinoma dormancy in vivo, UCSD Cancer Center Training Program in Drug Development, Regulation of Tumor Invasion and Metastasis by Matrix Stiffness
OpenAlex ID: W2343705268