Work

Inflammation and nutrition in children with chronic kidney disease

Year: 2016

Type: review

Abstract: Chronic inflammation and nutritional imbalance are important comorbid conditions that correlate with poor clinical outcomes in children with chronic kidney disease (CKD). Nutritional disorders such as cachexia/protein energy wasting, obesity and growth retardation negatively impact the quality of life and disease progression in children with CKD. Inadequate nutrition has been associated with growth disturbances in children with CKD. On the other hand, over-nutrition and obesity are associated with poor outcomes in children with CKD. The exact mechanisms leading to these unfavorable conditions are not fully elucidated and are most likely multifactorial. In this review, we focus on the pathophysiology of nutrition disorders and inflammation and their impact on clinical outcomes in children with CKD.

Source: World Journal of Nephrology

DOI: 10.5527/wjn.v5.i3.274

Authors: Juan Tu, Wai W Cheung, Robert H Mak

Institutions: University of California San Diego, Rady Children's Hospital-San Diego, Capital Institute of Pediatrics, Children's Hospital of Capital Institute of Pediatrics

Language: English

Topic: Dialysis and Renal Disease Management

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Bijzonder Onderzoeksfonds UGent