Work

Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription

Year: 2016

Type: article

Abstract: RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.

Source: Transcription

DOI: 10.1080/21541264.2016.1182240

Authors: N. S. Gerasimova, N. A. Pestov, O. I. Kulaeva, D. J. Clark, V. M. Studitsky

Institutions: Lomonosov Moscow State University, Rutgers, The State University of New Jersey, Fox Chase Cancer Center, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Russian Science Foundation, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: G156276794, G1667130490, G325520570, G3331264565